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A total of 3 % of active material is excreted in urine as unchanged active material. Tapentadol is additionally metabolised to N-desmethyl tapentadol (thirteen %) by CYP2C9 and CYP2C19 and also to hydroxy tapentadol (2 %) by CYP2D6, which happen to be even further metabolised by conjugation. Therefore, Lively material metabolism mediated by cytochr